Technical principle and advantages of Access automatic microplate preprocessor

Principle and technical advantages of Access automatic microplate preprocessor
The American Labcyte Echo 500 Series Non-Contact Nano-Upgrade Acoustic Pipetting System is the industry's most trusted micro-liquid pipetting system. Unlike other pipettes, they use a liquid-liquid (Move Liquids with Sound) instead of a tip or nozzle. The Echo 500 Series revolutionizes the pipetting system, which emits sound waves from beneath the holes in the source plate and “listens” to its echo to determine the composition of the liquid in the well and the height of the liquid, including the water content in the DMSO. . These are automated and take only a few microseconds to allow 2.5 nl of liquid to be accurately transferred to the corresponding hole in the inverted destination plate above it. This is the Acoustic Droplet Ejection (ADE: Acoustic Droplet Ejection) - a small amount of liquid is excited by sound waves to another microplate for pipetting. The large volume of liquid transfer is achieved by transferring hundreds of drops of liquid per second, and the Echo 555 can transfer up to 500 drops per second. The pipetting range is 2.5 to 10000 nl, and the extended transfer time can transfer a larger volume of liquid. Pipetting volume accuracy: less than 10% target volume deviation; precision: less than 8% CV.
Echo's non-contact nanoscale sonic pipetting system revolutionizes liquid transfer methods with sonic pipetting technology to improve experimental results and significantly reduce the cost of life science research. Access's Access laboratory workstation further maximizes the benefits of the Echo platform by automating the overall experimental throughput and repeatability. Like the larger POD automation platform, Access uses the same easy-to-operate Labcyte automation software, making it the fastest way to automate Echo sonic pipetting equipment. In the real plug-and-play trend, Access can perform all applications of Echo software, such as cherry picking, dose-response, plate reformatting, and more, quickly integrated into automated programs. Other applications. Within a few minutes, Echo sonic pipetting equipment can be converted into a fully automated liquid handling system for immediate use.
Access automates the Echo platform: 1) fully optimized at the time of use, without re-teach or fine-tuning system settings; 2) real easy to use through graphical, interface-guided software; 3) direct Echo application The solution is entered into an automated process; 4) configured to meet a wide range of application requirements; 5) to be connected to a laboratory information management system (LIMS) and database system; 6) to be safe for use in both chemical and biological environments.

Figure 1 shows the Access automatic microplate preprocessor in operation.

Access automatic microplate preprocessor in Figure 1

Figure 2 shows the structure of the Access automatic microplate preprocessor.
illustration:
Echo sonic pipetting equipment: Echo Liquid Handler;
Accessory Options: code reader, cover device;
Integration Options: sealers, centrifuges, dispensers, plate washers, plate readers, etc.;
Plate Storage Options: 50 microplate storage racks, 20 microplate random read storage racks (mixable configuration, up to 4 racks can be configured);
Also included are: system computers, functional connectivity centers, emergency system stop devices, and security accessories.
Figure 2 The composition of the Access fully automated microplate preprocessor.
The application-oriented Labcyte automation software allows Access and POD systems to automatically generate optimized automated processes by directly entering Echo application protocols. From a single interface on the system computer, or from an offline customer, the user can generate and edit the experimental scenario and add it to the run list. Automated programs can be edited or edited in advance while the system is running. Combined with Labcyte's automatic control software, any changes to the Echo application can be immediately recognized by the system software and any associated automation program can be automatically upgraded. If the automation is not adequately adjusted, the system software will guide the user through the use of tools such as "Microplate Storage Control" to resolve any problems that occur. If an error occurs, the Access and POD systems will guide the error recovery, allowing the user to continue running the experiment program quickly and easily. With the combination of Labcyte automation software and Echo application software, the automated process is optimized to ensure the maximum possible throughput of Echo sonic pipetting equipment.
The establishment of the automated process: the first step: input Echo application experimental program and the corresponding pipetting operation sequence list; the second step: according to the catalog to establish the microplate layout map (article map); the third step: dispatch Microplate processing tasks before and after operation. The establishment of the process has dynamic flexibility. After the automated process is established according to the creation wizard, the user can run the program instantly or at a set time. If the process needs to be changed, the priority can be changed on-the-fly. When the requirements of the experimental plan change, the user can also reverse the operation according to the creation wizard to make any adjustments to the process.
Advantages of Labcyte Automation
Labcyte Automation eliminates the drawbacks of custom automation: Laboratory automation solutions that use custom configurations often compromise overall performance and are unnecessarily complex. Through a single interface, Access combines the flexible Echo software application with the efficient process of Echo sonic pipetting equipment for the highest levels of performance. The Echo software application guides researchers through a range of options without sacrificing the application needs of the experiment for the convenience of automation. When the option is selected or edited, the graphical microplate layout can be updated immediately based on the final layout. This timely feedback quickly and visually determines that each experimental protocol provides high quality results as quickly as possible.
Software features include: Echo Plate Reformat: 1) Layout for pipetting from any hole in any hole; 2) Graphically designing a complex microplate layout to schedule experiments or experimental designs. Echo Cherry Pick: 1) It is convenient to enter a pipetting list; 2) Create a custom output file. Echo Dose Response: 1) Create curves based on a single protocol and pipetting list; 2) eliminate the need for additional replication; 3) reduce false negatives from dose response; 4) use less stored samples .
to sum up:
Access's fully automated microplate preprocessors meet your automation needs with revolutionary superior performance and convenience. Access optimizes any Echo sonic pipetting device and fully utilizes the Echo application. Its characteristics are as follows:
1) Direct input to all Echo applications;
2) All Echo certified microplates and plate covers are available;
3) Interchangeable sequential storage shelves and random storage shelves;
4) An on-the-fly can be established or created by a remote client;
5) The microplate catalog can be automatically compiled and the barcode can be determined;
6) can recover immediately from unexpected errors;
7) Add instruments to the workstation as needed;
8) It can be used immediately after installation;
9) All support is available directly from Labcyte;
10) Comply with CE/TUV standards.
For more information, please refer to the Labcyte website: and Shanghai Dian Biotech Co., Ltd. Website:
Shanghai Dian Biotech Co., Ltd. Contact: Room 2101, Building 6, Huiyang Building, 1139 Pudong Avenue, Shanghai. Tel: (+86) 21-58605185, fax: (+86) 21-51973282, E-mail:

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