According to a new issue of the US "Cell-Stem Cells" magazine, research conducted by Canadian researchers on mice showed that metformin, a commonly used type II diabetes drug, can promote brain cell division and new cell formation. This study shows that metformin is expected to be used in the treatment of Alzheimer's disease and other diseases in the future.
The main target of metformin is a special channel in the liver cells of diabetic patients. Canadian molecular geneticist Freda Miller and other researchers have found that metformin can also activate the same channels in experimental mouse brain cells and promote new brain cell growth.
This also holds true for human brain cells cultured in laboratory dishes. Miller said that newborn brain cells can repair the detrimental effects of neurodegenerative diseases such as Alzheimer's disease.
In 2008, studies showed that people with both diabetes and Alzheimer's disease had improved symptoms of Alzheimer's disease if they were taking metformin. At that time, scientists believed that the mechanism may be that metformin improves the patient's physical condition when treating diabetes, which helps to improve the symptoms of Alzheimer's disease.
Miller believes that their new research shows that metformin itself has a role in improving brain function. At present, Canadian researchers have begun clinical trials of metformin in the treatment of neurodegenerative diseases.
Metformin is a drug with a long-term safety record. Previous studies have shown that metformin can inhibit the growth of lung and breast tumors and reduce the risk of breast cancer in patients with diabetes.
The main target of metformin is a special channel in the liver cells of diabetic patients. Canadian molecular geneticist Freda Miller and other researchers have found that metformin can also activate the same channels in experimental mouse brain cells and promote new brain cell growth.
This also holds true for human brain cells cultured in laboratory dishes. Miller said that newborn brain cells can repair the detrimental effects of neurodegenerative diseases such as Alzheimer's disease.
In 2008, studies showed that people with both diabetes and Alzheimer's disease had improved symptoms of Alzheimer's disease if they were taking metformin. At that time, scientists believed that the mechanism may be that metformin improves the patient's physical condition when treating diabetes, which helps to improve the symptoms of Alzheimer's disease.
Miller believes that their new research shows that metformin itself has a role in improving brain function. At present, Canadian researchers have begun clinical trials of metformin in the treatment of neurodegenerative diseases.
Metformin is a drug with a long-term safety record. Previous studies have shown that metformin can inhibit the growth of lung and breast tumors and reduce the risk of breast cancer in patients with diabetes.
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