Release date: 2007-08-22
Targeted material under solid microscope can improve the detection rate of early colorectal cancer ----------------------------------- ---------------------------------------------
In recent years, the incidence of colorectal cancer in China has been increasing year by year. How to improve the diagnosis of early colorectal cancer from pathological means is one of the current research focuses. With the development of stained endoscopy and magnifying endoscopy and through the study of the type of colorectal mucosal opening and its relationship with different lesions, these new methods have been shown to help improve the detection rate of early colorectal cancer. How to locate lesions and target materials is the key to improve the early detection rate of colorectal cancer.
We used a routine colonoscopy of the Southern Hospital from August 2005 to December 2005 to perform endoscopic mucosal dissection of colorectal neoplastic lesions, with cases of suspected cancerous lesions ≥10 mm. Suspected lesions were found under colonoscopy, and local spray dyes adequately showed the extent of the lesion. The magnifying endoscope was used to observe the morphology of the glandular opening of the lesion and classify it, and the lesions of the tumor, such as tumor polyps or lateral developmental tumors, were removed. Pathological examination was performed on both targeted samples and random samples. According to the method of diagnostic pathology, the dysplasia was divided into mild (Class I), moderate (Class II) and severe (Class III) with the glandular opening classification method of Kudo?Mying. Irregular branches, bridging, and common walls form a sieve-like structure. The hyperplastic glands are considered as carcinoma in situ, and all pathological sections are diagnosed by two pathologists. A comparison of ≥10 mm specimens of adenoma dissection in the same period in 2004 (54, randomized) was performed.
Endoscopic examination revealed 38 cases of neoplastic lesions with a duct opening of IIIL, IV, and Vi. A total of 40 lesions were resected with a lesion diameter of 10 to 45 mm with an average of 18.95 mm. Of these tubular villus adenomas or villous adenomas ≥10 mm, most were associated with moderate to severe dysplasia (Table 1). The endoscopic exfoliated specimens were stained with mucosa, and the stereoscopic observation of the target was compared with conventional random sampling (Table 2). The former detected severe dysplasia (including precancerous lesions) accounted for 40% (16/). 40 cases), while the latter detected 2.5% (1/40 cases), the difference was significant (P < 0.001).
Severe dysplasia (including precancerous lesions) detected by random sampling in the same period of 2004 accounted for 7.4% (4/54 cases), which was significantly lower than that of targeted materials in 2005 (P<0.001, Table 2). Comparing the randomized materials in 2005 with the results of the randomized pathological examination in 2004, it was found that there was no significant difference in the detection rate of early colorectal cancer (including severe dysplasia) (P=0.341). Conventional pathological examination can only be performed without cutting, embedding and sectioning because it is difficult to observe the whole lesion. Clinically, it is often impossible to perform serial sectioning of whole tumors, and thus it is easy to miss a small and severe lesion (early colorectal cancer).
Endoscopic early colorectal cancer and moderate to severe dysplasia glandular opening (pit) are mostly IIIs, IV, Vi, Vn type, especially V type can be considered as early colorectal cancer, so by combining Enlarge the endoscopic and mucosal staining techniques to target the material, so that the focal microcarcinoma is not missed, and improve the diagnosis rate of early colorectal cancer. In this study, after endoscopic and mucosal staining for whole tumor biopsy, mucosal staining combined with solid microscopy was used for targeted biopsy. In 40 cases of suspected cancerous cases, 16 cases were diagnosed as early stage cancer (including severe dysplasia). The 16 specimens were randomly selected for examination, except for one case with pathological diagnosis of severe dysplasia, and the other 15 cases were mild or moderate dysplasia. Of the 54 patients randomized in the same period in 2004, only 4 early cancers (including severe dysplasia) were detected. In 2005, the detection rate of targeted dysplasia and carcinogenesis was 40%, which was significantly higher than the random sampling rate in 2004 and 2005. Pay attention to the pathological target material after whole tumor biopsy. Comprehensive application of magnifying endoscopic mucosal staining technique and solid microscopy after whole tumor biopsy can improve the detection rate of early colorectal cancer in China and standardize the pathological examination of flat lesions of large intestine.
—— Information from: Meditech Medical Network
Moringa oleifera, also known as horseradish tree, ben tree, or drumstick tree, is an economically important tree from India, Pakistan, and Nepal. Moringa has become popular as a natural leaf powder supplement, although the pods, roots, bark, flowers, seeds, and fruits are also edible. Moringa Leaf Extract Powder has a good reputation both at home and abroad as a new superfood for its highly nutritious profile and powerful anti-inflammatory, antioxidant, and tissue-protective properties among many other health benefits. Moringa Leaf Extract gains more popularity in China herbal plant market nowadays because of high pharmaceutical and industrial production value.
Moringa oleifera leaf extract powder as a popular natural supplement has many scientifically backed health benefits. It is rich in many important nutrients, including protein, vitamin B6, vitamin C, riboflavin and iron. Antioxidants fight free radicals, molecules that cause oxidative stress, cell damage, and inflammation but moringa contains antioxidants called flavonoids, polyphenols, and ascorbic acid. In addition, Moringa leaf concentrate can significantly lower inflammation that can lead to chronic diseases like diabetes, respiratory problems, cardiovascular disease, arthritis, and obesity. Moringa powder also has antibacterial and anti-fungal properties that fight infections. It's been effective against types of fungi that cause infections on skin and strains of bacteria responsible for blood and urinary tract infections and digestive problems. What`s more, moringa leaf extract has blood-clotting properties that benefit wound healing and can reduce clotting time, which means it reduces the time it takes for scratches, cuts, or wounds to stop bleeding.
Ningxia Pure Biology Technology Co.,Ltd (PURE Biotechnology) is a professional Chinese herb and tea supplier with 8 years experience. Valuable Chinese Chinese tea and its powder such as moringa leaf extract are supplied in various of packaging. This is a integrated company focus on raw herb and tea research, processing, marketing and export. The factory is located in Ningxia where the medicinal materials and Chinese teas are richly produced. Find your favorites moringa powder from Ningxia Pure Goji Bio-technology Co.,Ltd.
Dried Moringa Leaves,Moringa Leaves Tea,Moringa Oleifera Herb,Dried Moringa Leaves Tea
Ningxia Pure Biology Technology Co., Ltd. , https://www.pure-biotechnology.com