New coated stent is expected to overcome stent thrombosis

Release date: 2007-08-02

New coated stents are expected to overcome stent thrombosis SurModics (Nasdaq: SRDX) and Paragon have announced that they have signed an agreement to develop a new stent system for the treatment of coronary arteries. disease. The stent system combines SurModics' FINALE Prohealing coating technology with Paragon's unique thin-walled coronary stent system, designed to target stent thrombosis, a serious coronary stent. disease. According to interventional cardiologists, stent thrombosis is rare, but it is a potentially devastating complication for coronary stents. SurModics' FINALE promotes healing coating technology promotes the recovery of normal vascular structures and the healing of endothelial cells, not only to clear newly formed thrombi, but also to reduce restenosis. Combining this innovative technology with Paragon's thin-walled stent system, it is expected to produce a highly effective coronary stent with a biologic coating that not only has the efficacy of a drug-eluting stent, but also avoids long-term concerns about stent thrombosis. . Bruce Barclay, CEO of SurModics, said that we are pleased to work with Paragon and Apollo to develop such a new product, and that we have confidence in the preclinical findings of FINALE's healing coating technology. SurModics' FINALE-promoted coating technology incorporates extracellular matrix proteins (ECMs) that improve and accelerate tissue repair through the body's own healing mechanisms after implantation. Thrombosis or blood clots remain a very significant problem for coronary stents and are a major challenge for treatment teams and medical device companies that are actively seeking solutions. Incomplete or delayed regrowth of healthy endothelial cells after stent implantation may be a factor in new thrombosis. SurModics, in collaboration with Dr. Williams, hopes to accelerate the natural repair of blood vessels after stent implantation by adding ECM proteins to the coating. Dr. Williams is committed to developing new cardiovascular implant devices using tissue engineering technology and is a leading expert in this field. This technique is expected to rebuild the normal endothelial layer of blood vessels. SurModics collaborated with Dr. Williams and the University of Arizona on preclinical studies on FINALE coated stents with encouraging results. Apollo's coronary stents use Paragon's new technology to make the walls of the stents thinner and smaller in diameter, making them easier to transport when placed on the balloon of the catheter, and are easy to use. This new technology solves a common problem with stents by using advanced metallic materials such as alloy materials with cobalt substrates - most of which are retracted after installation on the catheter during production (slightly open) ). The new technology utilizes the properties of advanced metal materials to keep the stent tightly closed when mounted on a delivery catheter. ——Midi Medical Network

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