The AIDS that humans have been tackling on is finally getting medicine and healing. Can it be healed?
Gratifying human test data
Recently, a message about "Johnson announced the results of clinical trials of HIV vaccine: 100% of volunteers produce antibodies" was strongly screened.
On July 23, at the World AIDS Conference Virus Science Conference (IAS) in Paris, Johnson & Johnson's Yangsen Pharmaceutical announced the development of a AIDS preventive vaccine, the mosaic vaccine.
On July 24, Johnson & Johnson announced the results of the world's first human clinical trial of HIV vaccine. The vaccine was clinically tested in 393 healthy volunteers recruited in the United States, Rwanda, Uganda, South Africa and Thailand. The results showed that volunteers were resistant to mosaic vaccines. The sex is good and the antibody is produced 100%.
What is a mosaic vaccine? Is there such a magical power?
According to public information, the so-called mosaic vaccine, which uses a combination of multiple antigens (gene fragments) of HIV, forms a vaccine that has a strong stimulating effect on the body's immune system and can produce effective antibodies, called appROACH vaccine. The appROACH vaccine is first and foremost exciting. In addition to 100% anti-HIV antibody production in subjects, the risk of infection was reduced by 94% in a single exposure to HIV (HIV), and 66% were exposed to HIV 6 times. Still protected and not infected with HIV.
Mosaic vaccine
According to the Beijing Daily, the vaccine trial used the “primary-boosting†strategy, in which the subjects received a total of four vaccinations, the first two vaccines were priming, and the last two vaccines were booster vaccinations. After 48 weeks of injection, the subjects did not produce any side effects, and blood tests revealed antibodies against HIV in all humans. The risk of HIV infection was reduced by 94% in the actual assessment of the subject's protection.
The main reason for the significant effect of the AIDS mosaic vaccine is that the vaccine is designed according to the characteristics of HIV. The most important thing is to use multiple antigens of HIV, that is, genes from a plurality of different HIV subtype strains, which pass the viral vector. Generated to form a vaccine containing multiple HIV antigens.
Animal experiment completed 4 years ago
In 2013, researchers at Harvard Medical School and other institutions published a report on Cell, which they developed a "mosaic vaccine" that spliced ​​multiple genes. Animal experiments have shown that the vaccine can reduce the risk of HIV infection by about 90%. This research may bring new hope to human "anti-AIDS".
Scientists have long been suffering from the rapid evolutionary capabilities and diversity of HIV, and the “mosaic vaccine†is also called “mosaic vaccineâ€. It is based on the analysis of a large number of viral gene sequences and human immune responses. Optimized gene sequences produce vaccines that induce the body to produce a broader immune protection response covering all common HIV subtypes. After the large-scale clinical trial of AIDS vaccine RV144 in Thailand in 2009, it became the core research of AIDS vaccines preferred by researchers in various countries. At that time, large studies in Thailand showed that RV144 can only reduce the HIV infection rate by 31%, but it is already the most effective. vaccine.
The researchers also said that they have developed a "mosaic vaccine" using the three major proteins of HIV, Env, Gag and Pol. After inoculation of the vaccine to rhesus monkeys, the most pathogenic human monkey chimeric immunodeficiency The virus (SHIV), which simulates natural infections, attacks them six times in order to test the vaccine effect. At the end of the trial, the researchers found that although only 12 healthy rhesus monkeys were vaccinated after the virus had been attacked for six consecutive times, the calculations showed that 12 rhesus monkeys with and without vaccination (all after 3 attacks) Compared with infection, the "mosaic vaccine" has a protective effect on rhesus monkeys as high as 87% to 90%.
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