3D printing out mouse ovary artificial uterus / ovary becomes possible

The artificial uterus has made a major breakthrough this year! The Philadelphia Children's Hospital has created an external artificial uterus to sustain the survival of super-premature lambs. The lambs in the trial lived in the womb for 4 weeks, breaking the time record of the extrauterine device to maintain the stable function of the fetus.

The mortality rate of super-premature infants is high and there is no successful precedent for prolonging the in vitro system of pregnancy. This time, the scientists created a polyethylene film bag filled with artificial amniotic fluid that connects oxygen through the umbilical interface to form a closed fluid man-made environment. They were tested with super-premature lambs (equivalent to human preterm infants 23-24 weeks of gestation).

As a result, the eight lambs that grew in the artificial uterus did not differ significantly from the normal lambs. The results of this research bring hope to the rescue of very premature babies.

Also from the United States, humans used 3D printing technology for the first time to create a functional mouse ovary. This is a microwell scaffold of hydrogel material that supports mouse follicular cell development and can be used to restore ovarian function in surgically sterilized mice.

The scientists encapsulated the two ovarian cells into a 3D ovarian construct and implanted them into the rat. After transplantation, the cells in the ovary work normally and produce estrogen and progesterone stably in a 90-day experiment. Experiments have shown that these constructs can alleviate osteoporosis, weight changes, and uterine unhealthyness caused by hormone deficiency and ovarian loss.

Previous experiments showed that artificial ovaries gave birth to children in rats that had lost fertility. Human follicles are much larger than mice, and microwell scaffolds should be adjusted accordingly. Whether it can be successfully used in humans has to be tested.

Another interesting piece of information related to pregnancy is that pregnancy changes the brain structure of a new mother. Dutch scientists studied the brains of 25 first-born women and found that pregnancy caused structural changes in the brain for at least two years. These changes occur in areas related to social cognition and in areas where mothers respond to images of their babies. The degree of change also predicts how much the mother is attached to the child.

This year, the health sciences throw a bomb to public opinion, a nutrition paper published in The Lancet. Scientists tracked the dietary health of 135,000 respondents in 18 countries for a total of 7.4 years and concluded that they eat more fat and have a lower mortality rate; eat more carbohydrates and increase the risk of death; eat more saturated fat, stroke May be reduced.

Such an authoritative report is lively when it comes out. On the Internet, there was a rapid spread of "hot rice white noodles is a poison", "eat more staple foods to die fast", "eat more fat and less heart disease" and other hot articles, and some experts came out to question the paper.

The most objective argument is that the 18 countries of the sample focus on developing countries in Asia, Africa and Latin America, including China. 81% of the respondents are primary and secondary cultures, and 82% are moderate and heavy manual workers. It is not difficult to imagine that workers with insufficient meat consumption will eat more fish and meat to help their health; it is not too rare to conclude that the processed starch staple food is harmful to health.

Things are delicious because the body needs, but the appetite is often greedy, and the ancient genes make the body tend to prepare for disasters. Want to be healthy, eat less, eat a little bit, be wary of over-processed foods that are only available in modern life, such as refined sugar, heavy salt, but also remember that our ancestors are sports foraging, and we should not be too lazy. No nutrition paper has contradicted the above principles.

There are also advances in rejuvenation: there is a chemical that rejuvenates the old cells and regains the ability to split. This year, scientists reported that the resveratrol analogs naturally extracted from red, dark, red and blueberries were added to aging cells for only a few hours. The appearance and behavior of these cells rejuvenated, splitting again, and telomeres began. Lengthening (telomere length means cells can replicate multiple times). You have one more reason to throw red wine and chocolate into your shopping cart. You don't have to send melatonin to send health. (Technology Daily)

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