99% Purity Factory Supply Sarms Powder CAS 317318-84-6 Gw-0742 / Gw610742

99% Purity Factory Supply Sarms Powder CAS 317318-84-6 GW-0742 / GW610742


GW-0742 Quick Detail:

Name: GW-0742
Synonyms:GW0742;[4-[[[2-[3-Fluoro-4-(Trifluoromethyl)Phenyl]-4-Methyl-5-Thiazolyl]Methyl]Thio]-2-Methylphenoxy]Acetic Acid;4-[2-(3-Fluoro-4-Trifluoromethyl-Phenyl)-4-Methyl-Thiazol-5-Ylmethylsulfanyl]-2-Methyl-Phenoxy-Acetic Acid;4-[[[2-[3-Fluoro-4-(Trifluoromethyl)Phenyl]-4-Methyl-5-Thiazolyl]Methyl]Thio]-2-Methylphenoxy]Aceticacid;4-[2-(3-Fluoro-4-Trifluoromethyl-Phenyl)-4-Methyl-Thiazol-5-Ylmethylsulfanyl]- 2-Methyl-Phenoxy}-Acetic Acid;Acetic Acid, 2-[4-[[[2-[3-Fluoro-4-(Trifluoromethyl)Phenyl]-4-Methyl-5-Thiazolyl]Methyl]Thio]-2-Methylphenoxy]-;2-(4-(((2-(3-Fluoro-4-(Trifluoromethyl)Phenyl)-4-Methylthiazol-5-Yl)Methyl)Thio)-2-Methylphenoxy)
CAS:317318-84-6
MF: C21H17F4NO3S2
MW:471.49
Melting point:134.5-135.5 °C
Solubility:DMSO: >5 mg/mL
Chemical Properties:Light Yellow Solid
Uses:A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.

Biological Activity: Potent and highly selective PPAR δ agonist. EC 50 values are 0.001, 1.1 and 2 μ M for transactivation of human PPAR δ , - α , and - γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.
Packing:As required.

GW-0742 description:

The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.





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